Thymus mast cells as a component of neuro-endocrine-immune interactions under stress

Mast cells (MCs) are a required component of the thymus microenvironment. They affect intercellular interactions and permeability hematothymic barrier through cytokine production. There is speculation that site MCs formation deposition. under complex neuro-endocrine control they can play an important role in process acute transformation stress reaction, affecting extrathymic migration cells. The purpose this study to assess functional involvement at various hyper- hypodynamic effects during response without it. was conducted on male Wistar rats. factors were physical activity (swimming) different intensities immobilization, which represent two opposite states dynamic stress. classified histological preparations; degranulation coefficient mean histochemical (synthetic activity) calculated. In groups with preserved adrenal glands after exposure significant decrease mass noted, indicates weakening its development At same time, quickly respond These involved general reaction: their consists synchronous synthesis granules cytoplasm increased release active substances accumulated earlier. structure remain unchanged removed immobilization. No changes morphofunctional indicators mast detected either. Experiments hypo- hyperdinamic loading animals indicate largely determined by hypothalamic-pituitary-adrenal axis endocrine system. Removal (inability glucocorticoids) leads lack from MCs. stimulating effect glucocorticoids carried out combination other (catecholamines, corticotropin-releasing hormone, adrenocorticotropic hormone). When activated full-fledged reaction formed body, actively secretion. condition for adaptation mechanisms immune